Yeah it takes more than an actor to pull off comedy... it takes a comedic actor.
for that reason alone comedy can be hard to produce.
in my experience if your crew isn't laughing and trying to stay quite while your shooting then what you have on screen isn't going to connect with the audiences funny bone at home either. thats why in some comedy you will see outtakes of the same scene with 12 different lines. the comedic actor is trying to keep it fresh and keep the crew amused.