Ok I would go into after effects to make this one happen. It isn't hard if you have a handle on that massive app. but here are the sets I would go through to make it happen.
1. I would lock down the camera in on static position. If it moves it will be a motion graphics night mare. Then shoot some footage without you're talent. Then have you're talent go act out the scene as they would in you're script.
2. After you are happy with the takes turn the camera off record and import the footage into you're video editing software. Cut down the exact clip how it will be in you're final product. also make a clip of you're clean plate or the part without the talent so you can throw it behind the footage you want to use.
3. bring theses two clips into after effects and make new composition. Lay the shot with you're talent over the top of the shot without you're talent.
4. Now comes for the fun part. Create a mask over you're talent and go frame by frame moving it in a manner that mask out you're talent to reveal the clean plate be hind it. For this project it shouldn't take to much effort to make that one happen. I would say accomplish this one in no more than 10 frames, even less might sell the effect better.
5. Now go to detonationfilms.com find yerself some fire assets (stock footage) to lay over top of everything else. Compositing this shouldn't be that hard because their footage is generally in a luma matte format or already pre keyed. Adjust the size scale and rotation to you're liking key framing and tweening as needed. You may want to use a mask with a feather or the top of the fire assets to contain how far the graphic will extend out in you're final product. (they also have blood assest there that you may want to composite into the mix)
and wala there you have it somebody blowing up on film. This is a simple version of this effect there are more tutorials out there that can explain it better than I just did but hopefully this will give you a rough idea of how it is done.
check out
video copilot they have a good lighting strike tutorial that they have put together check them out. Remember also if you are going to do a good visual effect the audio effects will help sell it completely