To really drive home how Grandma feels she is a burden to everyone, you can't just have her say that. That's boring exposition. It needs to be shown through visual storytelling. She needs to be seen ambling through the home, having difficulty walking and moving with arthritis. Trying to be useful but failing at simple chores, like not rinsing the suds off the cook pots before drying them off, so the next dish cooked in them tastes like detergent. Thus annoying her family rather than helping. Being quarrelsome maybe. Being incontinent, then being unable to clean herself up on her own. That sort of thing.
The grandchildren may love her but they should also be part disgusted and part distracted with their own lives to live, which Grandma feels she is rather getting in the way of. They could be seen doing modern things Grandma fails to understand, like vlogging (disclosing information that used to be considered personal and private) or recording suggestive dance moves on tiktok that used to be considered obscene back in Grandma's days. Failing to be able to play video games with them. Grandma could get in the shots and embarrass them that way or just get on their nerves.
It would also help if the children were maybe even a bit older because otherwise she could still be useful looking after them while the parents are at work. Or alternatively, Grandma could be shown to fail and be unfit to behave responsibly any more by, say, falling for some telemarketer scam. Being unable to cope with the modern world and use its technology. Falling for far-right lies spread by an OAN-like cable station etc. It does not need to be elaborate, just a series of short, pointed vignettes.
Minor nitpicks, the stereotypical drinks of female alcoholics are cocktails and wine, not so much whiskey. Their stereotypical suicide methods do not include shooting themselves, especially not in the face or head. It is possible to break these conventions but it should be done with a clear goal in mind, an intention that enhances the narrative. I like it on a gut-feeling level. It could be jarring to basically make an old woman act out Mel Gibson's suicide attempt from Lethal Weapon in this manner. But I fail to see a clear-cut goal beyond that, and the whole manliness of it would seem to interfere with her characterization as fragile and self-conscious beyond the mere depression. Also it could easily become unintentionally funny.
Nick's line "That's not your choice Mom. I'm your guardian and I know what's best for you" seems a bit blunt. Legal guardian or no, family dynamics don't work that way. He wants to make things easy for himself and also he assumes he is still dealing with the gullible, doddering old fool from before. He would be trying to persuade or even convince her, pointing out the apparatus malfunction claiming that the doctor implied unlpeasant consequences, and that the follow-up is therefore in her own interest. He could also be trying to placate her while later being overheard mentioning to Rachel that they will just dump some sedative into Grandma's tea again if she continues to be a pain in the morning, and simply drag her to the doctor while she is drugged out.
Nick's line about the treatment being therapeutic and her not being dead feels too coherent for a man who has been bound and rendered defenseless while his mother starts cutting up his live body from the bottom up. More plausible utterances might be along the lines of "AAAAAAAAAA OH MY GOD PLEASE PLEASE STOP AAAAAAAAAA HELP MUM WHAT ARE YOU DOING OH GOD IT HURTS SO MUCH!!!"
Again, I'm not saying it wouldn't work, just that it is implausible and thus, surreal and absurd, which I don't feel was the intention.
GRANDMA's line with the marital spat sounds a bit contrived and stiff, maybe she could mention Nick and Rachel's names and hint at how they have been a bit stressed out, "you know how it is some days but they seem to have cleared the air now and gone to bed. Sometimes it's good to have things out, doncha agree, and tomorrow is another day." Then if he still wants to come inside, it would be even easier for her to deflect.
Final note, it all seems a bit short and pointless. The only character even surviving long enough to have a character arc is Airica. That makes her the protagonist. And that means she needs to be far more three-dimensional and fleshed out, and her transformation needs to be elaborated on. In order to achieve that, it would be good, for one thing, to set up early on the method by which she later dispatches the Monster instead of simply putting a gun in her hand. Even if she was only practicing dance moves or karate moves in the earlier tiktok video where Grandma got in the way, which she then uses somehow to incapacitate the Grandma monster. Something like that. Set it up - have it pay off.