I'd barely call them plot twists. The writers admitted to exploiting the human psychological tendency to connected unrelated things or events. I had fun watching them create a puzzle with no resolution (purposely) for about 3.5 seasons via Netflix - then I lost interest and start watching other stuff.
Lost had it moments while it held my interest; I might go back and finish it just for yucks. Too much other stuff that I find more interesting/inspiring visually or from a craft perspective. And besides, I've still got 11 season or so of Top Gear to roll through, haven't even begun The Wire or Boardwalk Empire, and I'm pretty sure I am least 2-3 seasons behind on Dexter.