EDIT: I'm a moron you weren't looking for suggestions
First off, bravo!! I only watched the first twenty minutes so far but the animation in the title sequence is worth that alone. Actor's seem very good for a low budget situation. Looks well shot.
Just on what I saw so far, my main comment would be regarding the comedic timing. It felt rushed to me and in the beginning, where I am trying to get a feel for the characters, it felt like a run away freight train. Not saying hit them over the head with it, but a half a beat or beat here and there might help. Looks like you have it covered well so a reaction shot here and there wouldn't hurt. Again, not talking about hanging on them, just a little breath here and there.
Also, not sure the music that is there now is doing you any favors. Maybe try a source track for the chardonnay scene, might make it feel organic and give some irony with the right track.
May want to look into trying to make it look a little more "film like" on your final color pass. Lighting is a little flat, so it looks very much like video.
I hear a little audio fluctuation during the chardonnay scene, which sounds like ADR, so you may want to give that another pass.
A small nit pic would be to reframe the shot of the blonde girl during the tryptic phone call. She's a little low in the frame and is throwing of sequence a bit.
I'll try to watch more later, but good job and congratulations. I know what a bear it is to get it done.