Gain on 0 always! Light well, then adjust the exposure in camera to the lighting. If you are wide open on the iris and are still having problems getting an image in the camera, you need more light - period.
1) If you've under lit and have to bring the image up in post, you'll get grain.
2) If the gain is up on the camera, you'll have grain.
The only way to solve the problem is to anticipate by over lighting slightly, then dropping the shadows and mids in post using a color corrector. Just like in film, fill in the shadows, you shouldn't have any "True" deep black shadows in camera... they should just barely touch black in camera.
The highlights should never cross "pure" white either... the solution is to light the dark parts of your image to the point where you can properly expose for the subject on the key light side while still being able to see into the shadows. This will give you the most freedom in post to correct the image to your tastes. The image you capture will look a bit washed out, but it's supposed to.
Darkening doesn't increase grain, lightening does. Avoid having to lighten in post.