I disagree with Sweetie, I can easily render footage that struggles to playback at all on my 12 core, 24GB RAM monster system. Try rendering and playing back a high quality animation png. The default quicktime player will blow up!
On a fastish SSD HDD?
Edit: I also assume you have a decent video card too. Maybe that's too much to assume sometimes.
Edit #2:
Source:
http://en.wikipedia.org/wiki/Uncompressed_video
1080i and 1080p HDTV uncompressed
8 bit @ 1920 x 1080 @ 24fps = 95 MB per/sec, or 334 GB per/hr.
10 bit @ 1920 x 1080 @ 24fps = 127 MB per/sec, or 445 GB per/hr.
8 bit @ 1920 x 1080 @ 25fps = 99 MB per/sec, or 348 GB per/hr.
10 bit @ 1920 x 1080 @ 25fps = 132 MB per/sec, or 463 GB per/hr.
8 bit @ 1920 x 1080 @ 29.97fps = 119 MB per/sec, or 417 GB per/hr.
10 bit @ 1920 x 1080 @ 29.97fps = 158 MB per/sec, or 556 GB per/hr.
1080i and 1080p HDTV RGB (4:4:4) uncompressed
10 bit @ 1280 x 720p @ 60fps = 211 MB per/sec, or 742 GB per/hr.
10 bit @ 1920 x 1080 @ 24fps = 190 MB per/sec, or 667 GB per/hr.
10 bit @ 1920 x 1080 @ 50i = 198 MB per/sec, or 695 GB per/hr.
10 bit @ 1920 x 1080 @ 60i = 237 MB per/sec, or 834 GB per/hr.
There are plenty of those settings (and higher up settings that would require higher bandwidth usage) that would make normal SATA3 drives sweat. The pausing comes from a bottleneck. When you're talking uncompressed formats, the bottleneck is sometimes the video card not being able to keep up with the raw data being thrown at it, other times its the hard drive not being able to keep up.
If its freezing, you're hitting a bottleneck somewhere. When there is little information to go by, it's hard to determine the cause.
Imagine what's required to play uncompressed 4k footage without freezing.